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Figure 5
Hypothalamic overexpression of CA-S6K leads to insulin resistance in the basal pancreatic clamp. (A) Protocol for surgery, viral injection, and the insulin clamp study. (B) Glucose infusion rate required to maintain euglycemia during the clamp period. (C) Glucose production during basal and clamp periods. (D) Clamp/basal HGP suppression ratio. (E) Peripheral glucose uptake during the clamp period. LZ, LacZ. **P < 0.01; ***P < 0.001.