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Figure 7
Hypothalamic overexpression of CA-S6K leads to insulin resistance under hyperinsulinemic-euglycemic clamp conditions. (A) Glucose infusion rate required to maintain euglycemia during the clamp period. (B) Glucose production during basal and clamp periods. (C) Clamp/basal HGP suppression ratio. (D) Peripheral glucose uptake during the clamp period. (E) Phosphoserine IRS-1 and (F) phosphoserine S6 at the end of the clamp study. Graphs show the ratio of phosphoproteins to total proteins. *P < 0.05 versus LacZ. **P < 0.01.