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Figure 6
MAPK pathway pharmacological blockade increases rapamycin-mediated growth inhibition in vitro. (A and B) Effect of rapamycin (Rapa; 20 nM), UO126 (10 μM), or the combination of both on cell growth (A) and BrdU incorporation (B; after 24 hours of treatment; n = 4). **P < 0.01 compared with vehicle-treated cells; ^#P < 0.05 and ^##P > 0.01 compared with rapamycin-treated cells; ^$P < 0.05 and ^$$P < 0.01 compared with UO126-treated cells. Error bars indicate SD.