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Figure 3
Modest efficacy of rapamycin and PD0325901 for treatment of androgen-dependent prostate cancer. (A) Diagram of the experimental strategy, as per Figure 1. (B–U) Representative tissue sections from the Nkx3.1^+/—Pten^+/— mutant mice treated with the single agent or combination of agents, showing histological phenotype (H&E) and immunostaining for the antibodies indicated. H&E analyses were performed on all experimental mice in each group; immunohistochemistry was done on a minimum of 4 animals from each group; representative data are shown. Scale bars: 100 μm.