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Figure 7
Cardiomyopathy in CAR-cKO mice. (A) Histological findings in WT and CAR-cKO mouse hearts at 25 weeks of age stained with H&E, trichrome, and picro-sirius red demonstrating myocardial fibrosis. Original magnification, ×200 (lower 6 panels). (B and C) Echocardiographic analysis of CAR-cKO mice showed cardiomyopathy starting around 21 weeks of age (B). The heart weight/tibia length (HW/TBL) ratio was not significantly different between WT and CAR-cKO mice. LV end-diastolic dimension (LVDD), LV end-systolic dimension (LVSD), and fractional shortening (FS) are shown quantitatively (C). n = 5 for each group tested. Error bars show mean ± SEM. **P < 0.01 versus WT by Student’s t test.