B cell receptor revision diminishes the autoreactive B cell response after antigen activation in mice
J. Clin. Invest. Ying-Hua Wang, et al. 118:2896 doi:10.1172/JCI35618 [Go to this article.]

Figure 4
Inhibition of RAG leads to decrease of l chain expression. (A) qPCR for l chain expression (Igl-V1) on Tet⁺B220^lo cells. Mice were immunized with DWEYS-MAP and treated with anti–IL-7R antibody or isotype control as described in Figure 3, and spleen cells were sorted on day 16. The experiment was performed twice. (B and C) ELISA of serum levels of l chain associated with IgM (B) or IgG (C) from immunized mice. Arrows indicate the time of injection of anti–IL-7R antibody or isotype control on days 8, 11, and 14. Data are the mean ± SEM of 5 mice in each group. The P value was determined by 2-way ANOVA.