B cell receptor revision diminishes the autoreactive B cell response after antigen activation in mice
J. Clin. Invest. Ying-Hua Wang, et al. 118:2896 doi:10.1172/JCI35618 [Go to this article.]

Figure 5
Receptor revision contributes to tolerance maintenance in peptide-induced autoimmunity. BALB/c mice were immunized with DWEYS-MAP peptide and administered anti–IL-7R antibody or isotype control as described in Figure 3. Eight weeks after the primary immunization, the mice were boosted one more time with DWEYS-MAP in incomplete Freund adjuvant. Anti-dsDNA (A) and antipeptide (B) IgG serum antibodies were measured by ELISA after the boost. Data are the mean ± SEM of 5 mice in each group, representative of 2 independent experiments. The P value was determined by 2-way ANOVA.