Platelet glycoprotein Ibα forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF
J. Clin. Invest. Tadayuki Yago, et al. 118:3195 doi:10.1172/JCI35754 [Go to this article.]

Figure 1
Platelets roll on different vWF site densities with biphasic velocity curves that align with wall shear stress but not with wall shear rate. Platelets suspended in medium without or with 6% Ficoll were perfused through a flow chamber containing immobilized vWF in a range of flow rates. The flow chamber was coated with 100 μg/ml (A–C) or 440 μg/ml (C) vWF, resulting in the site densities shown in C. The rolling velocity is plotted versus the wall shear rate (A) or wall shear stress (B and C). Data are mean ± SD of 5 experiments.