Platelet glycoprotein Ibα forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF
J. Clin. Invest. Tadayuki Yago, et al. 118:3195 doi:10.1172/JCI35754 [Go to this article.]

Figure 2
As force increases, GPIbα forms catch bonds and then slip bonds with WT A1, but forms only slip bonds with R1306Q A1 and R1450E A1. (A, C, and D) Lifetimes of single GPIbα bonds with WT A1 (A), R1306Q A1 (C), or R1450E A1 (D) were measured by AFM. Data are mean ± SEM of several tens of measurements for each point. (B) Lifetimes of platelets or 1-μm-radius microspheres bearing GPIbα transiently tethered to a flow chamber floor coated with 2 μg/ml WT A1 were measured. Data are mean ± SD of 3 experiments.