Platelet glycoprotein Ibα forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF
J. Clin. Invest. Tadayuki Yago, et al. 118:3195 doi:10.1172/JCI35754 [Go to this article.]

Figure 3
Unfixed and fixed platelets roll with biphasic velocity curves on WT A1, but with monophasic velocity curves on R1306Q A1 and R1450E A1. Unfixed or fixed platelets in medium without or with Ficoll (to increase the viscosity by 2.6-fold) were perfused through a flow chamber containing immobilized WT A1 (A and B), R1306Q A1 (C and D), or R1450E A1 (E and F) in a range of flow rates. The rolling velocity is plotted versus the wall shear rate (A, C, and E) or wall shear stress (B, D, and F). Data are mean ± SD of 5 experiments.