Surfactant protein-B deficiency
LM Nogee - Chest, 1997 - journal.chestnet.org
(CHEST 1997; 111: 129S) prostacyclin synthase (PGIS) is the final committed enzymatic
step in the pathway of prostacyclin (PGI2) production, occurring at a branch point where
substrate (PGH2) can be directed either toward prostacyclin, which affords protection, or
thromboxane, which augments injury. The imbalance of prostacydin and thromboxanc is
involved in the pathogenesis of several diseases, such as pulmonary hypertension, acute
lung injury, and atherosclerosis. These studies were designed to pursue the molecular …
step in the pathway of prostacyclin (PGI2) production, occurring at a branch point where
substrate (PGH2) can be directed either toward prostacyclin, which affords protection, or
thromboxane, which augments injury. The imbalance of prostacydin and thromboxanc is
involved in the pathogenesis of several diseases, such as pulmonary hypertension, acute
lung injury, and atherosclerosis. These studies were designed to pursue the molecular …
