[HTML][HTML] Generation of specific deoxynojirimycin-type inhibitors of the non-lysosomal glucosylceramidase
HS Overkleeft, GH Renkema, J Neele… - Journal of Biological …, 1998 - ASBMB
The existence of a non-lysosomal glucosylceramidase in human cells has been
documented (van Weely, S., Brandsma, M., Strijland, A., Tager, JM, and Aerts, JMFG (1993)
Biochim. Biophys. Acta 1181, 55–62). Hypothetically, the activity of this enzyme, which is
localized near the cell surface, may influence ceramide-mediated signaling processes. To
obtain insight in the physiological importance of the non-lysosomal glucosylceramidase, the
availability of specific inhibitors would be helpful. Here we report on the generation of …
documented (van Weely, S., Brandsma, M., Strijland, A., Tager, JM, and Aerts, JMFG (1993)
Biochim. Biophys. Acta 1181, 55–62). Hypothetically, the activity of this enzyme, which is
localized near the cell surface, may influence ceramide-mediated signaling processes. To
obtain insight in the physiological importance of the non-lysosomal glucosylceramidase, the
availability of specific inhibitors would be helpful. Here we report on the generation of …
