Induction of severe intrauterine growth retardation in the Sprague-Dawley rat
HP Van Geijn, WM Kaylor Jr, KR Nicola… - American journal of …, 1980 - Elsevier
A noninvasive technique in an animal model that consistently produces severe intrauterine
growth retardation in the Sprague-Dawley rat is described. Maternal rats were exposed
continuously to a hypoxic environment (9.5% oxygen) between days 10 and 22 of gestation.
This oxygen concentration was marginal for the survival of the Sprague-Dawley rat fetus.
The results demonstrate decreases of 61% in litter size, 36% in fetal body weight, and 23%
in fetal brain weight. The effect of hypoxia was differentiated from that of a reduced voluntary …
growth retardation in the Sprague-Dawley rat is described. Maternal rats were exposed
continuously to a hypoxic environment (9.5% oxygen) between days 10 and 22 of gestation.
This oxygen concentration was marginal for the survival of the Sprague-Dawley rat fetus.
The results demonstrate decreases of 61% in litter size, 36% in fetal body weight, and 23%
in fetal brain weight. The effect of hypoxia was differentiated from that of a reduced voluntary …
