Transforming growth factor-β1 and fibrosis in congenital muscular dystrophies
P Bernasconi, C Di Blasi, M Mora, L Morandi… - Neuromuscular …, 1999 - Elsevier
We evaluated transforming growth factor-β1 (TGF-β1) expression in the muscle of four
laminin α2-negative, four laminin α2-positive and seven partial laminin α2-deficient
congenital muscular dystrophy (CMD) patients, and compared it to Duchenne muscular
dystrophy (DMD) patients and controls. TGF-β1 mRNA levels in skeletal muscle from laminin
α2-negative and laminin α2-positive CMD patients were significantly greater than in controls
(P< 0.05 and P< 0.005, respectively), while in partial laminin α2-deficient muscular …
laminin α2-negative, four laminin α2-positive and seven partial laminin α2-deficient
congenital muscular dystrophy (CMD) patients, and compared it to Duchenne muscular
dystrophy (DMD) patients and controls. TGF-β1 mRNA levels in skeletal muscle from laminin
α2-negative and laminin α2-positive CMD patients were significantly greater than in controls
(P< 0.05 and P< 0.005, respectively), while in partial laminin α2-deficient muscular …
