Flow of cerebral interstitial fluid as indicated by the removal of extracellular markers from rat caudate nucleus
HF Cserr, DN Cooper, TH Milhorat - Experimental eye research, 1977 - Elsevier
Bulk flow of interstitial fluid (ISF) in brain was studied by following the intracerebral
distribution of horseradish peroxidase (HRP) injected into the caudate nucleus of rats. Using
this technique, channels of ISF flow are outlined as the extracellular pathways of protein
distribution away from the injection site. Anionic isoenzymes of HRP were separated from
Sigma's Type II HRP using ion-exchange chromatography. Anionic isoenzymes proved
superior as markers of ISF flow, presumably because there is less cellular uptake and …
distribution of horseradish peroxidase (HRP) injected into the caudate nucleus of rats. Using
this technique, channels of ISF flow are outlined as the extracellular pathways of protein
distribution away from the injection site. Anionic isoenzymes of HRP were separated from
Sigma's Type II HRP using ion-exchange chromatography. Anionic isoenzymes proved
superior as markers of ISF flow, presumably because there is less cellular uptake and …
