Apoptosis, also known as programmed cell death, is the major type of cell death involved in
normal development, regeneration, proliferation and pathologic degeneration in the central
nervous system (CNS). The apoptotic process can be divided further into two pathways
depending on the involvement of mitochondria and related biochemical cascades. The
internal pathway of apoptosis is initiated by a variety of cytotoxic stimuli and mediated by the
release of cytochrome c and subsequent activation of downstream caspases. The external …