Evidence for an interferon-related inflammatory reaction in the trisomy 16 mouse brain leading to caspase-1-mediated neuronal apoptosis
DM Hallam, NL Capps, AL Travelstead… - Journal of …, 2000 - Elsevier
The trisomy of human chromosome 21 (Down syndrome) is the leading genetic cause of
learning difficulties in children, and predisposes this population to the early onset of the
neurodegeneration of Alzheimer's disease. Down syndrome is associated with increased
interferon (IFN) sensitivity resulting in unexpectedly high levels of IFN inducible gene
products including Fas, complement factor C3, and neuronal HLA I which could result in a
damaging inflammatory reaction in the brain. Consistent with this possibility, we report here …
learning difficulties in children, and predisposes this population to the early onset of the
neurodegeneration of Alzheimer's disease. Down syndrome is associated with increased
interferon (IFN) sensitivity resulting in unexpectedly high levels of IFN inducible gene
products including Fas, complement factor C3, and neuronal HLA I which could result in a
damaging inflammatory reaction in the brain. Consistent with this possibility, we report here …
