High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages
A Veillette, E Thibaudeau, S Latour - Journal of Biological Chemistry, 1998 - ASBMB
SHPS-1 (or SIRP) is a member of the immunoglobulin (Ig) superfamily abundantly
expressed in neurons and other cell types. Within its cytoplasmic domain, it possesses at
least two immunoreceptor tyrosine-based inhibitory motifs, which are targets for tyrosine
phosphorylation and mediate the recruitment of SHP-2, an Src homology 2 (SH2) domain-
containing protein-tyrosine phosphatase. Since other immunoreceptor tyrosine-based
inhibitory motifs-containing receptors have critical roles in the negative regulation of …
expressed in neurons and other cell types. Within its cytoplasmic domain, it possesses at
least two immunoreceptor tyrosine-based inhibitory motifs, which are targets for tyrosine
phosphorylation and mediate the recruitment of SHP-2, an Src homology 2 (SH2) domain-
containing protein-tyrosine phosphatase. Since other immunoreceptor tyrosine-based
inhibitory motifs-containing receptors have critical roles in the negative regulation of …
