[HTML][HTML] Tuberculosis as a three-act play: A new paradigm for the pathogenesis of pulmonary tuberculosis
RL Hunter - Tuberculosis, 2016 - Elsevier
Lack of access to human tissues with untreated tuberculosis (TB) has forced generations of
researchers to use animal models and to adopt a paradigm that granulomas are the
characteristic lesion of both primary and post primary TB. An extended search of studies of
human lung tissues failed to find any reports that support this paradigm. We found scores of
publications from gross pathology in 1804 through high resolution CT scans in 2015 that
identify obstructive lobular pneumonia, not granulomas, as the characteristic lesion of …
researchers to use animal models and to adopt a paradigm that granulomas are the
characteristic lesion of both primary and post primary TB. An extended search of studies of
human lung tissues failed to find any reports that support this paradigm. We found scores of
publications from gross pathology in 1804 through high resolution CT scans in 2015 that
identify obstructive lobular pneumonia, not granulomas, as the characteristic lesion of …