Inhibition of reticulon-1a–mediated endoplasmic reticulum stress in early AKI attenuates renal fibrosis development
Several animal studies have shown an important role for endoplasmic reticulum (ER) stress
in AKI, whereas human studies are lacking. We recently reported that Reticulon-1A (RTN1A)
is a key mediator of ER stress and kidney cell injury. Here, we investigated whether
modulation of RTN1A expression during AKI contributes to the progression to CKD. In a
retrospective study of 51 patients with AKI, increased expression of RTN1A and other ER
stress markers were associated with the severity of kidney injury and with progression to …
in AKI, whereas human studies are lacking. We recently reported that Reticulon-1A (RTN1A)
is a key mediator of ER stress and kidney cell injury. Here, we investigated whether
modulation of RTN1A expression during AKI contributes to the progression to CKD. In a
retrospective study of 51 patients with AKI, increased expression of RTN1A and other ER
stress markers were associated with the severity of kidney injury and with progression to …
