ER stress induced impaired TLR signaling and macrophage differentiation of human monocytes
T Komura, Y Sakai, M Honda, T Takamura, T Wada… - Cellular …, 2013 - Elsevier
Endoplasmic reticulum (ER) stress causes impairment of the intracellular protein synthesis
machinery, affecting various organ functions and homeostasis systems, including immunity.
We found that ER stress induced by the N-linked glycosylation inhibitor, tunicamycin, caused
susceptibility to apoptosis in the human monocytic cell line, THP-1 cells. Importantly, prior to
tunicamycin-induced apoptosis, the proinflammatory response to toll-like receptor (TLR) 4
ligand lipopolysaccharide (LPS) stimulation was attenuated with respect to the expression of …
machinery, affecting various organ functions and homeostasis systems, including immunity.
We found that ER stress induced by the N-linked glycosylation inhibitor, tunicamycin, caused
susceptibility to apoptosis in the human monocytic cell line, THP-1 cells. Importantly, prior to
tunicamycin-induced apoptosis, the proinflammatory response to toll-like receptor (TLR) 4
ligand lipopolysaccharide (LPS) stimulation was attenuated with respect to the expression of …
