Human kidney peritubular capillaries are particularly susceptible to injury, resulting in
dysregulated angiogenesis, capillary rarefaction and regression, and progressive loss of
kidney function. However, little is known about the structure and function of human kidney
microvasculature. Here, we isolated, purified, and characterized human kidney peritubular
microvascular endothelial cells (HKMECs) and reconstituted a three-dimensional human
kidney microvasculature in a flow-directed microphysiologic system. By combining epithelial …