Role of CCR2 in macrophage migration into the liver during acetaminophen-induced hepatotoxicity in the mouse
DM Dambach, LM Watson, KR Gray, SK Durham… - Hepatology, 2002 - Elsevier
The biological effects of monocyte chemoattractant protein (MCP) 1 are mediated by binding
to CC chemokine receptor (CCR) 2. In the present studies, we used CCR2 knockout
(CCR2−/−) mice to examine the role of MCP-1 in acetaminophen-induced macrophage
accumulation in the liver, expression of inflammatory cytokines, and hepatotoxicity. We
found that hepatic expression of CCR2 and MCP-1 was increased 10-fold and 20-fold,
respectively, 12 to 72 hours after administration of acetaminophen to wild-type mice …
to CC chemokine receptor (CCR) 2. In the present studies, we used CCR2 knockout
(CCR2−/−) mice to examine the role of MCP-1 in acetaminophen-induced macrophage
accumulation in the liver, expression of inflammatory cytokines, and hepatotoxicity. We
found that hepatic expression of CCR2 and MCP-1 was increased 10-fold and 20-fold,
respectively, 12 to 72 hours after administration of acetaminophen to wild-type mice …