The importance of the interaction between hepatocyte and hepatic stellate cells in fibrogenesis induced by fatty accumulation
PJ Giraudi, VJB Becerra, V Marin… - … and molecular pathology, 2015 - Elsevier
Background & aims Non-alcoholic fatty liver disease is characterized by an initial
accumulation of triglycerides that can progress to non-alcoholic steatohepatitis, which can
ultimately evolve to cirrhosis and hepatocellular carcinoma. Hepatic stellate cells play a key
role in liver fibrogenesis by an increased activation and an altered profile of genes involved
in the turnover of extracellular matrix components. To reproduce in-vitro the functional cell
connections observed in vivo it is essential to consider cell-to-cell proximity and interaction …
accumulation of triglycerides that can progress to non-alcoholic steatohepatitis, which can
ultimately evolve to cirrhosis and hepatocellular carcinoma. Hepatic stellate cells play a key
role in liver fibrogenesis by an increased activation and an altered profile of genes involved
in the turnover of extracellular matrix components. To reproduce in-vitro the functional cell
connections observed in vivo it is essential to consider cell-to-cell proximity and interaction …
