The intrahepatic biliary epithelium is a target of the growth hormone/insulin-like growth factor 1 axis
BACKGROUND/AIMS: We evaluated the role and mechanisms by which the GH/IGF1 axis
modulates cholangiocyte proliferation. METHODS: GH-receptors (GH-R), IGF1, IGFBP3
(binding protein 3), IGF1-R and receptor substrates (IRS) were evaluated in cholangiocytes
of normal or bile duct-ligated (BDL) rat livers. The effects of GH and IGF1 on proliferation of
normal quiescent cholangiocytes and the transduction pathways involved were investigated.
RESULTS: IGF1, GH-R, IGF1-R, IRS-1/2 were expressed in normal cholangiocytes and …
modulates cholangiocyte proliferation. METHODS: GH-receptors (GH-R), IGF1, IGFBP3
(binding protein 3), IGF1-R and receptor substrates (IRS) were evaluated in cholangiocytes
of normal or bile duct-ligated (BDL) rat livers. The effects of GH and IGF1 on proliferation of
normal quiescent cholangiocytes and the transduction pathways involved were investigated.
RESULTS: IGF1, GH-R, IGF1-R, IRS-1/2 were expressed in normal cholangiocytes and …