[HTML][HTML] NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasL-and NKG2D-dependent …
A Glässner, M Eisenhardt, B Krämer, C Körner… - Laboratory …, 2012 - Elsevier
In mouse models it has been shown that natural killer (NK) cells can attenuate liver fibrosis
via killing of activated hepatic stellate cells (HSCs) in a NKG2D-and tumor necrosis factor-
related apoptosis-inducing ligand (TRAIL)-dependent manner. However, only little data exist
regarding interactions of human NK cells with HSCs and their potential role in hepatitis C
virus (HCV)-associated fibrogenesis. Therefore, purified NK cells from untreated HCV RNA
(+) patients (n= 33), interferon-α (IFN-α)-treated patients (n= 17) and healthy controls (n= 18) …
via killing of activated hepatic stellate cells (HSCs) in a NKG2D-and tumor necrosis factor-
related apoptosis-inducing ligand (TRAIL)-dependent manner. However, only little data exist
regarding interactions of human NK cells with HSCs and their potential role in hepatitis C
virus (HCV)-associated fibrogenesis. Therefore, purified NK cells from untreated HCV RNA
(+) patients (n= 33), interferon-α (IFN-α)-treated patients (n= 17) and healthy controls (n= 18) …