From the more than 100 liver diseases described, many of those with high incidence rates
manifest themselves by histopathological changes, such as hepatitis, alcoholic liver disease,
fatty liver disease, fibrosis, and, in its later stages, cirrhosis, hepatocellular carcinoma,
primary biliary cirrhosis and other disorders. Studies of disease pathogeneses are largely
based on integrating-omics data pooled from cells at different locations with spatial
information from stained liver structures in animal models. Even though this has led to …