[HTML][HTML] Pathogenic roles of tumor necrosis factor receptor p55–mediated signals in dimethylnitrosamine-induced murine Liver fibrosis
K Kitamura, Y Nakamoto, M Akiyama, C Fujii… - Laboratory …, 2002 - Elsevier
TNF-α has pleiotropic functions, but its role in liver fibrosis has not yet been clarified. To
understand the pathophysiologic role of the TNF-α/TNF receptor (TNFR) p55 signals in liver
fibrosis, 10 mg/kg of dimethylnitrosamine, a specific hepatotoxicant, was administered twice
a week into the peritoneal cavity of both TNFRp55 knock-out (KO) and wild-type mice, and
the severity of fibrosis was monitored histologically and biochemically. In wild-type mice,
histologic analysis demonstrated evident fibrotic changes 1 week after the initiation of …
understand the pathophysiologic role of the TNF-α/TNF receptor (TNFR) p55 signals in liver
fibrosis, 10 mg/kg of dimethylnitrosamine, a specific hepatotoxicant, was administered twice
a week into the peritoneal cavity of both TNFRp55 knock-out (KO) and wild-type mice, and
the severity of fibrosis was monitored histologically and biochemically. In wild-type mice,
histologic analysis demonstrated evident fibrotic changes 1 week after the initiation of …
