Origin and fate of proliferated hepatic ductal cells in the rat: electron microscopic and autoradiographic studies
JW Grisham, EA Porta - Experimental and Molecular Pathology, 1964 - Elsevier
Hepatic bile ductal cells are distinctively different in several morphological aspects from
hepatocytes. Under a variety of conditions in which ductal cells proliferate in rat liver, this
distinction remains, and cells possessing characteristics intermediate between the two were
not seen in this study. Autoradiography with H 3 TdR showed that the increased numbers of
ductal cells arose by mitotic proliferation from pre-existing ductal cells and that hepatocytes
arose from pre-existing hepatocytes. Furthermore, there was no evidence of significant …
hepatocytes. Under a variety of conditions in which ductal cells proliferate in rat liver, this
distinction remains, and cells possessing characteristics intermediate between the two were
not seen in this study. Autoradiography with H 3 TdR showed that the increased numbers of
ductal cells arose by mitotic proliferation from pre-existing ductal cells and that hepatocytes
arose from pre-existing hepatocytes. Furthermore, there was no evidence of significant …
