Cytokine gene expression by kupffer 4cells in experimental alcoholic liver disease
S Kamimura, H Tsukamoto - Hepatology, 1995 - Elsevier
Kupffer cell-derived cytokines are believed to play pivotal paracrine roles in the
pathogenesis of alcoholic liver disease (ALD). To evaluate this hypothesis, Kupffer cell gene
expression of tumor necrosis factor-alpha (TNFα), interleukin (IL)-6, and transforming growth
factor-beta 1 (TGFβ1) were directly examined in the rat model of ALD. Kupffer cells were
isolated from the model after 10 and 17 weeks of intragastric ethanol infusion. These two
durations resulted in focal hepatocellular injury and liver fibrogenesis, respectively …
pathogenesis of alcoholic liver disease (ALD). To evaluate this hypothesis, Kupffer cell gene
expression of tumor necrosis factor-alpha (TNFα), interleukin (IL)-6, and transforming growth
factor-beta 1 (TGFβ1) were directly examined in the rat model of ALD. Kupffer cells were
isolated from the model after 10 and 17 weeks of intragastric ethanol infusion. These two
durations resulted in focal hepatocellular injury and liver fibrogenesis, respectively …