Hepatic activation of IKK/NFκB signaling induces liver fibrosis via macrophage-mediated chronic inflammation
Y Sunami, F Leithäuser, S Gul, K Fiedler, N Güldiken… - Hepatology, 2012 - journals.lww.com
Liver damage in humans is induced by various insults including alcohol abuse, hepatitis B/C
virus infection, autoimmune or metabolic disorders and, when persistent, leads to
development of liver fibrosis. Because the nuclear factor-κB (NF-κB) system is activated in
response to several of these stresses, we hypothesized that NF-κB activation in hepatocytes
may contribute to fibrosis development. To activate the NF-κB signaling pathway in a time-
and cell-type-specific manner in the liver, we crossed transgenic mice carrying the …
virus infection, autoimmune or metabolic disorders and, when persistent, leads to
development of liver fibrosis. Because the nuclear factor-κB (NF-κB) system is activated in
response to several of these stresses, we hypothesized that NF-κB activation in hepatocytes
may contribute to fibrosis development. To activate the NF-κB signaling pathway in a time-
and cell-type-specific manner in the liver, we crossed transgenic mice carrying the …
