[PDF][PDF] Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp
NA Hibberts, AF Howell, VA Randall - Journal of Endocrinology, 1998 - vipadenievolos.ru
NA Hibberts, AF Howell, VA Randall
Journal of Endocrinology, 1998•vipadenievolos.ruAndrogens can gradually transform large scalp hair follicles to smaller vellus ones, causing
balding. The mechanisms involved are unclear, although androgens are believed to act on
the epithelial hair follicle via the mesenchymederived dermal papilla. This study investigates
whether the levels and type of androgen receptors in primary lines of cultured dermal papilla
cells derived from balding scalp hair follicles differ from those of follicles from non-balding
scalp. Androgen receptor content was measured by saturation analysis using the non …
balding. The mechanisms involved are unclear, although androgens are believed to act on
the epithelial hair follicle via the mesenchymederived dermal papilla. This study investigates
whether the levels and type of androgen receptors in primary lines of cultured dermal papilla
cells derived from balding scalp hair follicles differ from those of follicles from non-balding
scalp. Androgen receptor content was measured by saturation analysis using the non …
Abstract
Androgens can gradually transform large scalp hair follicles to smaller vellus ones, causing balding. The mechanisms involved are unclear, although androgens are believed to act on the epithelial hair follicle via the mesenchymederived dermal papilla. This study investigates whether the levels and type of androgen receptors in primary lines of cultured dermal papilla cells derived from balding scalp hair follicles differ from those of follicles from non-balding scalp.
Androgen receptor content was measured by saturation analysis using the non-metabolisable androgen,[3H] mibolerone (0· 05–10 nM) in a 9–10 point assay. Pubic dermal fibroblasts and Shionogi cells were examined as positive controls. Repetitive assays of Shionogi cells showed good precision in the levels of androgen receptor content (coefficient of variation= 3· 7%). Specific, high affinity, low capacity androgen receptors were detected in dermal
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