Bleomycin produces DNA damage, apoptosis and senescence, all of which play crucial
roles in the development of pulmonary fibrosis. Recently, close attention has been paid to a
DNA damage-induced phenotypic change (senescence-associated secretory phenotype;
SASP) as a trigger for the secretion of various mediators which modify the processes of
tissue injury, inflammation, repair and fibrosis. We characterized the SASP in a murine
model of bleomycin-induced lung injury. Mice were intratracheally administered bleomycin …