Hyaluronan regulates bone morphogenetic protein-7-dependent prevention and reversal of myofibroblast phenotype
AC Midgley, L Duggal, R Jenkins, V Hascall… - Journal of Biological …, 2015 - ASBMB
Hyaluronan (HA) promotes transforming growth factor (TGF)-β1-driven myofibroblast
phenotype. However, HA can also have disease-limiting activity. Bone morphogenetic
protein-7 (BMP7) is an antifibrotic cytokine that antagonizes TGF-β1, and isolated studies
have demonstrated that HA can both mediate and modulate BMP7 responses. In this study,
we investigated whether BMP7 can modulate HA in a manner that leads to
prevention/reversal of TGF-β1-driven myofibroblast differentiation in human lung fibroblasts …
phenotype. However, HA can also have disease-limiting activity. Bone morphogenetic
protein-7 (BMP7) is an antifibrotic cytokine that antagonizes TGF-β1, and isolated studies
have demonstrated that HA can both mediate and modulate BMP7 responses. In this study,
we investigated whether BMP7 can modulate HA in a manner that leads to
prevention/reversal of TGF-β1-driven myofibroblast differentiation in human lung fibroblasts …
