Reversal of cirrhosis: an achievable goal of hepatitis B antiviral therapy
YF Liaw - Journal of hepatology, 2013 - journal-of-hepatology.eu
Background: Whether long-term suppression of replication of hepatitis B virus (HBV) has any
beneficial effect on regression of advanced liver fibrosis associated with chronic HBV
infection remains unclear. We aimed to assess the effects on fibrosis and cirrhosis of at least
5years' treatment with tenofovir disoproxil fumarate (DF) in chronic HBV infection. Methods:
After 48weeks of randomised double-blind comparison (trials NCT00117676 and
NCT00116805) of tenofovir DF with adefovir dipivoxil, participants (positive or negative for …
beneficial effect on regression of advanced liver fibrosis associated with chronic HBV
infection remains unclear. We aimed to assess the effects on fibrosis and cirrhosis of at least
5years' treatment with tenofovir disoproxil fumarate (DF) in chronic HBV infection. Methods:
After 48weeks of randomised double-blind comparison (trials NCT00117676 and
NCT00116805) of tenofovir DF with adefovir dipivoxil, participants (positive or negative for …
