Loss of matrix metalloproteinase-13 attenuates murine radiation-induced pulmonary fibrosis
P Flechsig, B Hartenstein, S Teurich, M Dadrich… - International Journal of …, 2010 - Elsevier
PURPOSE: Pulmonary fibrosis is a disorder of the lungs with limited treatment options.
Matrix metalloproteinases (MMPs) constitute a family of proteases that degrade extracellular
matrix with roles in fibrosis. Here we studied the role of MMP13 in a radiation-induced lung
fibrosis model using a MMP13 knockout mouse. METHODS AND MATERIALS: We
investigated the role of MMP13 in lung fibrosis by investigating the effects of MMP13
deficiency in C57Bl/6 mice after 20-Gy thoracic irradiation (6-MV Linac). The morphologic …
Matrix metalloproteinases (MMPs) constitute a family of proteases that degrade extracellular
matrix with roles in fibrosis. Here we studied the role of MMP13 in a radiation-induced lung
fibrosis model using a MMP13 knockout mouse. METHODS AND MATERIALS: We
investigated the role of MMP13 in lung fibrosis by investigating the effects of MMP13
deficiency in C57Bl/6 mice after 20-Gy thoracic irradiation (6-MV Linac). The morphologic …
