Loss of TIMP3 enhances interstitial nephritis and fibrosis
Z Kassiri, GY Oudit, V Kandalam, A Awad… - Journal of the …, 2009 - journals.lww.com
The balance of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix
metalloproteinases (TIMPs) determines the integrity of the extracellular matrix. TIMP3 is the
most highly expressed tissue inhibitor of metalloproteinase (TIMP) in the kidney, but its
function in renal disease is incompletely understood. In this study, TIMP3−/− mice
demonstrated an age-dependent chronic tubulointerstitial fibrosis. After unilateral ureteral
obstruction (UUO), young TIMP3−/− mice exhibited increased renal injury (tubular atrophy …
metalloproteinases (TIMPs) determines the integrity of the extracellular matrix. TIMP3 is the
most highly expressed tissue inhibitor of metalloproteinase (TIMP) in the kidney, but its
function in renal disease is incompletely understood. In this study, TIMP3−/− mice
demonstrated an age-dependent chronic tubulointerstitial fibrosis. After unilateral ureteral
obstruction (UUO), young TIMP3−/− mice exhibited increased renal injury (tubular atrophy …
