CELL CYCLE 2017, VOL. 16, NO. 21, 1997-1998 https://doi. org/10.1080/15384101.2017. 1377500 support tissue regeneration and to limit aging phenotypes through various mechanisms. 7 Therefore, we suggest that rapid elimination of senescent cells following p21 silencing may not only limit the damage, induced by the presence of senescent cells, but also promote a better recovery of tissues due to an increase in its regenerative capacity. Inhibition of p21 may provide an efficient way to treat both fibrotic and non-fibrotic age-related pathologies. Overall, p21 silencing, reveals central molecular mechanisms responsible for maintaining the viability and retention of senescent cells in tissues, and suggests that the elimination of senescent cells by inhibition of these mechanisms represents a promising strategy to target senescent cells in order to promote tissue fitness and extend health-span and lifespan.