A theory of marginotomy: the incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon
AM Olovnikov - Journal of theoretical biology, 1973 - Elsevier
A theory of marginotomy has been proposed to explain the limitation of the cell doubling
potential of clones of normal somatic cells. Marginotomy of DNA is the shortening of the
replica with respect to the template. Two possible mechanisms of marginotomy are
discussed. The first mechanism is a DNA-polymerase, postulated to have a catalytically
inactive zone lying between the catalytic centre and the outer edge of the enzyme molecule.
The terminal template segment which is equal to the length of the non-catalytic marginal …
potential of clones of normal somatic cells. Marginotomy of DNA is the shortening of the
replica with respect to the template. Two possible mechanisms of marginotomy are
discussed. The first mechanism is a DNA-polymerase, postulated to have a catalytically
inactive zone lying between the catalytic centre and the outer edge of the enzyme molecule.
The terminal template segment which is equal to the length of the non-catalytic marginal …
