RECENT evidence indicates that an impairment of neuronal adaptive and reparative
processes might be a key feature of the pathomechanism of Alzheimer's disease.
Aberrations in the reparative neuronal response are likely to result from alterations of
intracellular signal transduction cascades. As a consequence of abnormal intracellular
signalling, the activation of those molecular events might be triggered in neurones which, in
dividing cells, would lead to cellular transformation. In the present study, changes in the …