This review describes the aspects of leukotriene (LT) pharmacology and biology that are
relevant to their important role in asthma. The biosynthesis and metabolism, including
transcellular metabolism, of LTB4and the cysteinyl-LTs (ie LTC4, LTD4and LTE4) are
described, and their transport is briefly outlined. The existence, distribution and
pharmacological characterization of the receptors (BLT, CysLT1, CysLT2), as well as the
transduction mechanisms triggered, are discussed in detail. We also describe their effects …