Lactosylceramide mediates tumor necrosis factor-α-induced intercellular adhesion molecule-1 (ICAM-1) expression and the adhesion of neutrophil in human umbilical …
AK Bhunia, T Arai, G Bulkley, S Chatterjee - Journal of Biological Chemistry, 1998 - ASBMB
The endothelial expression of adhesion molecules by proinflammatory cytokines such as
tumor necrosis factor-α (TNF-α) has been suggested to contribute to the initiation of
atherosclerotic plaque formation. Since lactosylceramide (LacCer) accumulates in large
quantities in human atherosclerotic plaque, we have explored its role in TNF-α-induced
expression of intercellular adhesion molecule-1 (ICAM-1) in human umbilical vein
endothelial cells and their consequent adhesion to polymorphonuclear leukocytes (PMNs) …
tumor necrosis factor-α (TNF-α) has been suggested to contribute to the initiation of
atherosclerotic plaque formation. Since lactosylceramide (LacCer) accumulates in large
quantities in human atherosclerotic plaque, we have explored its role in TNF-α-induced
expression of intercellular adhesion molecule-1 (ICAM-1) in human umbilical vein
endothelial cells and their consequent adhesion to polymorphonuclear leukocytes (PMNs) …
