Aspirin-triggered 15-epi-lipoxin A4 signals through FPR2/ALX in vascular smooth muscle cells and protects against intimal hyperplasia after carotid ligation
MH Petri, A Laguna-Fernandez… - International …, 2015 - internationaljournalofcardiology.com
The benefit of aspirin is well established in cardiovascular prevention, and involves the
irreversible inhibition of platelet cyclooxygenase (COX)-1 and, as a consequence,
decreased thromboxane levels [1]. In addition to inhibition of platelet aggregation, aspirin
may also have anti-inflammatory properties, with potential additional benefit in
atherosclerosis prevention. Acetylation of the COX-2 enzyme by aspirin directs the
metabolism of polyunsaturated fatty acids (PUFAs) towards a biosynthetic pathway, which in …
irreversible inhibition of platelet cyclooxygenase (COX)-1 and, as a consequence,
decreased thromboxane levels [1]. In addition to inhibition of platelet aggregation, aspirin
may also have anti-inflammatory properties, with potential additional benefit in
atherosclerosis prevention. Acetylation of the COX-2 enzyme by aspirin directs the
metabolism of polyunsaturated fatty acids (PUFAs) towards a biosynthetic pathway, which in …
