Gfi1–cells and circuits: unraveling transcriptional networks of development and disease
Current opinion in hematology, 2010•journals.lww.com
Gfi1 is central to several transcriptional circuits whose dysregulation leads to abnormal or
malignant hematopoiesis. These functional relationships are conserved from Drosophila
development. Such conserved pathways represent central oncogenic or
'gatekeeper'pathways that are pivotal to understanding the process of cellular
transformation, and illustrate key targets for clinical intervention.
malignant hematopoiesis. These functional relationships are conserved from Drosophila
development. Such conserved pathways represent central oncogenic or
'gatekeeper'pathways that are pivotal to understanding the process of cellular
transformation, and illustrate key targets for clinical intervention.
Summary
Gfi1 is central to several transcriptional circuits whose dysregulation leads to abnormal or malignant hematopoiesis. These functional relationships are conserved from Drosophila development. Such conserved pathways represent central oncogenic or ‘gatekeeper’pathways that are pivotal to understanding the process of cellular transformation, and illustrate key targets for clinical intervention.
Lippincott Williams & Wilkins