Both androgen action and PI3K medicated signaling pathways have been implicated in
prostate tumorigenesis. Our androgen receptor (AR) conditional transgenic mice developed
murine prostatic intraepithelial neoplasia (mPIN) and prostatic adenocarcinoma lesions
recapitulating human prostate cancer development and progression. Role of transgenic AR
contributing to malignancy was demonstrated by high degree of transgenic AR expression in
atypical and tumor cells in mPIN as well as prostatic adenocarcinoma lesions of the …