O2 sensing, mitochondria and ROS signaling: the fog is lifting
GB Waypa, KA Smith, PT Schumacker - Molecular aspects of medicine, 2016 - Elsevier
Mitochondria are responsible for the majority of oxygen consumption in cells, and thus
represent a conceptually appealing site for cellular oxygen sensing. Over the past 40 years,
a number of mechanisms to explain how mitochondria participate in oxygen sensing have
been proposed. However, no consensus has been reached regarding how mitochondria
could regulate transcriptional and post-translational responses to hypoxia. Nevertheless, a
growing body of data continues to implicate a role for increased reactive oxygen species …
represent a conceptually appealing site for cellular oxygen sensing. Over the past 40 years,
a number of mechanisms to explain how mitochondria participate in oxygen sensing have
been proposed. However, no consensus has been reached regarding how mitochondria
could regulate transcriptional and post-translational responses to hypoxia. Nevertheless, a
growing body of data continues to implicate a role for increased reactive oxygen species …
