Excitotoxicity caused by excessive stimulation of glutamate receptors, resulting in
pathologically increased Ca 2+-concentrations, is a decisive factor in neurodegenerative
diseases. We investigated long-term changes in synaptic contents of AMPA receptor
subunits that play important roles in calcium regulation in chronic epilepsy. Such plastic
changes may be either adaptive or detrimental. We used a kainic acid (KA)-based rat model
of chronic temporal lobe epilepsy (TLE). Using hippocampal synaptosomes, we found …