Autoimmune GFAP astrocytopathy: prospective evaluation of 90 patients in 1 year
D Dubey, SR Hinson, EA Jolliffe, A Zekeridou… - Journal of …, 2018 - Elsevier
In this prospective evaluation of serum and CSF samples, all but two CSF GFAPα-IgG
positive patients had autoimmune meningoencephalomyelitis while serum GFAPα-IgG
positivity alone was less specific. Phenotypes were diverse among patients that were serum
positive only. Adult and pediatric clinical presentations were similar. Most patients were
immunotherapy responsive. Co-existing NMDA-R-IgG and cancer were associated with lack
of response to first-line immunotherapy. Among patients with follow-up information, 18% had …
positive patients had autoimmune meningoencephalomyelitis while serum GFAPα-IgG
positivity alone was less specific. Phenotypes were diverse among patients that were serum
positive only. Adult and pediatric clinical presentations were similar. Most patients were
immunotherapy responsive. Co-existing NMDA-R-IgG and cancer were associated with lack
of response to first-line immunotherapy. Among patients with follow-up information, 18% had …