Unexplained seizures, confusion or hallucinations: think Hashimoto encephalopathy
J Alink, TW De Vries - Acta Paediatrica, 2008 - Wiley Online Library
J Alink, TW De Vries
Acta Paediatrica, 2008•Wiley Online LibraryAim: Hashimoto encephalopathy (HE) is a serious but treatable condition that is probably
underdiagnosed. We summarize and review all published cases to delineate the disease
and to alert paediatricians so that they recognize the disease in children. Methods: We
searched three data sources, PubMed, Cochrane and Embase, to find the articles on the
subject. Results: Twenty‐five children (85.8% girls) were reported being diagnosed with HE.
The median age was 14 years (range 9–18 years). The most frequent clinical symptoms …
underdiagnosed. We summarize and review all published cases to delineate the disease
and to alert paediatricians so that they recognize the disease in children. Methods: We
searched three data sources, PubMed, Cochrane and Embase, to find the articles on the
subject. Results: Twenty‐five children (85.8% girls) were reported being diagnosed with HE.
The median age was 14 years (range 9–18 years). The most frequent clinical symptoms …
Abstract
Aim: Hashimoto encephalopathy (HE) is a serious but treatable condition that is probably underdiagnosed. We summarize and review all published cases to delineate the disease and to alert paediatricians so that they recognize the disease in children.
Methods: We searched three data sources, PubMed, Cochrane and Embase, to find the articles on the subject.
Results: Twenty‐five children (85.8% girls) were reported being diagnosed with HE. The median age was 14 years (range 9–18 years). The most frequent clinical symptoms were seizures (80%), confusion (52%), headache (40%), hallucinations (32%) and ataxia (36%). Antimicrosomal antibodies were demonstrated in all patients, other diagnostic methods were not specific. Treatment with steroids was effective with 55% of patients showing complete recovery.
Conclusion: We recommend measuring antimicrosomal antibodies in all children with unexplained seizures, hallucinations or confusion and, if positive, initiating treatment with prednisolone.
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