High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study
TZ Baram, WC Mitchell, A Tournay, OC Snead III… - …, 1996 - publications.aap.org
Objective. To compare the efficacy of corticotropin (ACTH)(150 U/m2/day) and prednisone (2
mg/kg/day), given for 2 weeks, in suppressing clinical spasms and hypsarrhythmic
electroencephalogram (EEG) in infantile spasms (IS). ACTH and prednisone are standard
treatments for IS. ACTH at high doses causes severe dose-and duration-dependent side
effects, but may be superior to prednisone, based on retrospective or uncontrolled studies.
Blinded prospective studies have shown equal efficacy of prednisone and low-dose ACTH …
mg/kg/day), given for 2 weeks, in suppressing clinical spasms and hypsarrhythmic
electroencephalogram (EEG) in infantile spasms (IS). ACTH and prednisone are standard
treatments for IS. ACTH at high doses causes severe dose-and duration-dependent side
effects, but may be superior to prednisone, based on retrospective or uncontrolled studies.
Blinded prospective studies have shown equal efficacy of prednisone and low-dose ACTH …